1-up Archives

The Trend Reduction In COVID-19 Daily Deaths.

30 April 2022

SARS-CoV-2 Was Waving A White Flag By June 2020. Since the onset of the Great Insanity we have been following the COVID-19 mortality rate and total deaths on a daily basis, as mortality rate is ultimately the best measure of infectivity, i.e. the damage to human health that a pathogen can cause. For an explanation […]

What Makes SARS-CoV-2 More Infectious.

12 February 2022

The Role Of The RBM:ACE2 Interface. A little over a year ago, we set out how increased infectiousness meant greater vulnerability, i.e. a new variant may be more infectious but it is also more susceptible to destruction by the innate immune response. The chances are that most people now know what a structural spike protein […]

SARS-COV-2’s Defences Against Detection.

18 May 2021

What Variants Want. Considerable coverage is being given to variant B1.617. This is the ‘Indian’ variant if you use the incorrect basis of giving single country, geographical names to variants that appear globally across multiple variants and are not new, having been in existence for months and in some cases, over a year. As part […]

Why The S Protein Is Not The Target You Are Looking For.

11 February 2021

The First Lesson Of Camouflage – Not Being Seen. The majority of vaccines and antivirals both in use and in development as SARS-CoV-2 countermeasures target the structural Spike protein. We have highlighted previously that as the S protein trimers contain the RBDs, the S protein houses the virion’s principal weapon and is therefore the obvious, […]

Clap For Chris – The Greatest Scientist…NOT.

6 February 2021

This Man Is Supposed To Be In Charge. Earlier this week, the Chief Medical Officer was heckled in the street by someone who disagreed with him. Perhaps not the most appropriate way to make your point – even if the point being made was absolutely correct – but if you are a true leader and […]

More Infectious Equals More Vulnerable.

28 January 2021

Infectiousness And Infectivity Are Not The Same. Infectiousness is how easily a pathogen can spread and infectivity is the level of disease severity it can cause. We explained this in more detail earlier this month in response to the UK government’s regular – and one would predicate deliberate – confusion of the two. S-VoC / […]