immunoevasion Archives

Why The S Protein Is Not The Target You Are Looking For.

11 February 2021

The First Lesson Of Camouflage – Not Being Seen. The majority of vaccines and antivirals both in use and in development as SARS-CoV-2 countermeasures target the structural Spike protein. We have highlighted previously that as the S protein trimers contain the RBDs, the S protein houses the virion’s principal weapon and is therefore the obvious, […]

More Infectious Equals More Vulnerable.

28 January 2021

Infectiousness And Infectivity Are Not The Same. Infectiousness is how easily a pathogen can spread and infectivity is the level of disease severity it can cause. We explained this in more detail earlier this month in response to the UK government’s regular – and one would predicate deliberate – confusion of the two. S-VoC / […]

Exoribonuclease – Your Starter For Ten Mr Prime Minister.

30 December 2020

Q1. How can a virus containing an exoribonuclease mutate in the way you are saying? Coronaviruses possess an exoribonuclease within nonstructural protein 14 (nsp14-ExoN). This functions as a proofreader during viral transcription and encoding, ensuring high fidelity replication. This minimises the potential for mutation, as shown by the fact that sarbecovirus/lineage B betacoronaviruses with their […]

PCR Testing Is Picking Up The Common Cold.

23 December 2020

Mutation = Phylogenetic Evolution. Not content with inventing the most recent ‘killer mutation of death’, there are now apparently even more new strains of the ‘killer virus of death’ (the one that continues to not kill people, especially those it infects). There is now even one supposedly from South Africa (“this is an illegal mutating, […]

Mutation Makes A Vaccine Useless.

20 December 2020

Epitopes And Paratopes. Apparently the killer virus of death (the one that continues to not kill people, especially those it infects) has now mutated into an even more killer strain. If that’s true – which it isn’t, read on to find out why – then wonderdrug vaccine BNT126b2 is nothing of the sort: it was […]

Avoid Any Experimental Vaccine.

6 December 2020

The Right Vaccine Can Be Good. Few would disagree – us included – that vaccines per se are a good thing. Over the decades vaccines have been created that have eradicated or allowed the prevention of truly horrible diseases such as smallpox, polio, measles, hepatitis A & B, mumps, diptheria and whooping cough. Those of […]

Monetising A Vaccine Shows What It’s Really All About.

7 November 2020

LOADSAMONEY! According to the sales pitch on Thursday from investment banks Credit Suisse and Morgan Stanley, a COVID-19 vaccine could be a “bumper revenue opportunity“, projected to earn at least $10 billion a year. Morgan Stanley’s projection is at least $10 billion a year across developed countries but Credit Suisse is bigging it up further […]

An antiviral maybe but a vaccine isn’t needed and wouldn’t be effective.

20 October 2020

Apparently everything now hangs on a vaccine: stockmarkets rise and fall on the mere rumour of how the rumoured development of a particular rumoured COVID-19 vaccine is going; politicians say that normality can’t be resumed until a vaccine is available; people are fed the line that a virus must have a vaccine and that without […]

Recombination and re-recombination: how SARS-CoV-2 mixes it up.

7 September 2020

Lots of coverage is given to talking about how ‘the coronavirus’ could mutate and spawn new and ever more deadly strains – this despite it apparently already being the most deadly virus in the history of the world ever, which you would think doesn’t really leave it any scope to get worse – as part […]

The lack of sunlight. Yet another reason why lockdown has made the situation far worse.

6 July 2020

This is something about which we have been writing for months and now with every passing day, there is an increasing body of evidence that shows lockdown was not only ineffective – and therefore unnecessary – but also that it made the situation worse. Worse as in it was responsible for the deaths of thousands, […]