nonstructural protein Archives

How Each Of Us Causes Every Variant.

31 January 2022

The Four Nucleobases. Almost exactly twelve months ago, we explained how increased transmissibility also meant greater vulnerability, i.e. a new variant may be more infectious but it is also more susceptible to detection by the immune system. This was first evidenced by our study of SARS-CoV-2-SG614, also one year ago now. Despite there being virtually […]

Nitric Oxide’s Role In Anti-Adhesion And Anti-Coagulation.

13 December 2021

Background. SARS-CoV-2’s Achilles’ heel has always been vitamin D in general and nitric oxide in particular. We first explained the relevance of vitamin D in July 2020, identifying the correlation between vitamin D deficiency and COVID-19 mortality rates and the key role of exposure to photosynthesis of vitamin D from exposure to UVB that occurs […]

Cathelicidin – Another Key Benefit Of Vitamin D.

29 October 2021

Background. It is impossible to ignore the pivotal role of vitamin D both in preventing SARS-CoV-2 viral infection (through the eNOS→nitric oxide pathway) and in reducing COVID-19 disease severity (through the cholecalciferol→ calcifediol→calcitriol pathway). As early as July 2020 we had identified the positive correlation between COVID-19 mortality rate and vitamin D deficiency. By October […]

SARS-COV-2’s Defences Against Detection.

18 May 2021

What Variants Want. Considerable coverage is being given to variant B1.617. This is the ‘Indian’ variant if you use the incorrect basis of giving single country, geographical names to variants that appear globally across multiple variants and are not new, having been in existence for months and in some cases, over a year. As part […]

Is Ivermectin Another ‘Wonderdrug’?

21 April 2021

Is This Remdesivirmania Redux? Ivermectin is the subject of increasing coverage and concomitant hysteria around it being another ‘wonderdrug’ for the treatment of SARS-CoV-2. It has been touted as a potential treatment since the days of remdesivir, chloroquine, hydroxychloroquine and lopinavir. We picked apart remdesivir in October 2020, days after it was approved by the […]

Rhinoviruses Increase SARS-CoV-2 Immunity.

31 March 2021

Persistent Antigen Exposure. We first highlighted persistent antigen exposure back in November 2020, when our research showed that individuals who had not previously had SARS-CoV-2 possessed memory T cells that recognised it, with this recognition likely coming from previous exposure to other common cold-causing coronaviruses. Public Health England that commissioned the report stated (with our […]

Exoribonuclease – Your Starter For Ten Mr Prime Minister.

30 December 2020

Q1. How can a virus containing an exoribonuclease mutate in the way you are saying? Coronaviruses possess an exoribonuclease within nonstructural protein 14 (nsp14-ExoN). This functions as a proofreader during viral transcription and encoding, ensuring high fidelity replication. This minimises the potential for mutation, as shown by the fact that sarbecovirus/lineage B betacoronaviruses with their […]

Mutation Makes A Vaccine Useless.

20 December 2020

Epitopes And Paratopes. Apparently the killer virus of death (the one that continues to not kill people, especially those it infects) has now mutated into an even more killer strain. If that’s true – which it isn’t, read on to find out why – then wonderdrug vaccine BNT126b2 is nothing of the sort: it was […]

Having A Common Cold Is As Good As A Vaccine.

15 December 2020

Learn From The Common Cold. Pretty much everybody now knows that four coronaviruses cause the common cold: duvinacovirus alphacoronavirus HCoV-229E & setracovirus alphacoronavirus HCoV-NL63 and embecovirus or lineage A betacoronaviruses HCoV-HKU1 and HCoV-OC43. That’s the common cold that you can catch over & over and which is dealt with by the innate immune system only, […]

Avoid Any Experimental Vaccine.

6 December 2020

The Right Vaccine Can Be Good. Few would disagree – us included – that vaccines per se are a good thing. Over the decades vaccines have been created that have eradicated or allowed the prevention of truly horrible diseases such as smallpox, polio, measles, hepatitis A & B, mumps, diptheria and whooping cough. Those of […]