nsp7 Archives

Is Ivermectin Another ‘Wonderdrug’?

21 April 2021

Is This Remdesivirmania Redux? Ivermectin is the subject of increasing coverage and concomitant hysteria around it being another ‘wonderdrug’ for the treatment of SARS-CoV-2. It has been touted as a potential treatment since the days of remdesivir, chloroquine, hydroxychloroquine and lopinavir. We picked apart remdesivir in October 2020, days after it was approved by the […]

IgA – Faster, Stronger and More Effective.

11 March 2021

The Star Player On Your Team. Following seroconversion, immumoglobulin A (IgA) istoype is the most frequently created antibody in the immune system. This is principally because it dominates the upper respiratory tract, which is usually the first point of contact between pathogen and human. Therefore, it is needed more frequently than the other isotypes. As […]

Why The S Protein Is Not The Target You Are Looking For.

11 February 2021

The First Lesson Of Camouflage – Not Being Seen. The majority of vaccines and antivirals both in use and in development as SARS-CoV-2 countermeasures target the structural Spike protein. We have highlighted previously that as the S protein trimers contain the RBDs, the S protein houses the virion’s principal weapon and is therefore the obvious, […]

Antibody-Dependent Enhancement And This Rushed ‘Vaccine’.

19 January 2021

What is Antibody-Dependent Enhancement? As we have set out previously, it takes 10-15 years to develop a vaccine. This timescale is entirely understandable and justifiable when you consider that the vaccine has to be both effective and safe. Safe includes not causing unacceptable side effects, which include the vaccine or immune system’s response triggering autoimmunity, […]

Exoribonuclease – Your Starter For Ten Mr Prime Minister.

30 December 2020

Q1. How can a virus containing an exoribonuclease mutate in the way you are saying? Coronaviruses possess an exoribonuclease within nonstructural protein 14 (nsp14-ExoN). This functions as a proofreader during viral transcription and encoding, ensuring high fidelity replication. This minimises the potential for mutation, as shown by the fact that sarbecovirus/lineage B betacoronaviruses with their […]

Having A Common Cold Is As Good As A Vaccine.

15 December 2020

Learn From The Common Cold. Pretty much everybody now knows that four coronaviruses cause the common cold: duvinacovirus alphacoronavirus HCoV-229E & setracovirus alphacoronavirus HCoV-NL63 and embecovirus or lineage A betacoronaviruses HCoV-HKU1 and HCoV-OC43. That’s the common cold that you can catch over & over and which is dealt with by the innate immune system only, […]

Avoid Any Experimental Vaccine.

6 December 2020

The Right Vaccine Can Be Good. Few would disagree – us included – that vaccines per se are a good thing. Over the decades vaccines have been created that have eradicated or allowed the prevention of truly horrible diseases such as smallpox, polio, measles, hepatitis A & B, mumps, diptheria and whooping cough. Those of […]

The Common Cold And SARS-CoV-2 Immunity.

30 November 2020

No Vaccine Required. Is it possible that the common cold could can provide immunity through memory T cells to a significant proportion of a population? In recent articles we have highlighted various other reasons why a vaccine is not required. This include; those not at risk (that’s over 99%) don’t need one and those at […]

Déjà vu – memory T cells have seen SARS-CoV-2 before.

23 November 2020

Newly-Discovered Is Not New. In early September we first highlighted the incorrect designation of SARS-CoV-2 as a ‘novel’ or ‘new’ coronavirus when it should have been designated ‘newly-discovered’. There is a subtle but fundamental difference: something that is new did not previously exist whereas something that is newly-discovered already existed but not been discovered yet. […]