PAMP Archives

Exoribonuclease – Your Starter For Ten Mr Prime Minister.

30 December 2020

Q1. How can a virus containing an exoribonuclease mutate in the way you are saying? Coronaviruses possess an exoribonuclease within nonstructural protein 14 (nsp14-ExoN). This functions as a proofreader during viral transcription and encoding, ensuring high fidelity replication. This minimises the potential for mutation, as shown by the fact that sarbecovirus/lineage B betacoronaviruses with their […]

These Are Not The Drugs You Are Looking For.

20 November 2020

Don’t Use Remdesivir. Just one month after the US Food and Drug Administration approved remdesivir as an antiviral for the treatment of patients with COVID-19, the WHO yesterday recommended that it not be used, on the basis that it is ineffective and there is “no evidence” it reduces mortality. Last month, we analysed remdesivir’s use […]

Monetising A Vaccine Shows What It’s Really All About.

7 November 2020

LOADSAMONEY! According to the sales pitch on Thursday from investment banks Credit Suisse and Morgan Stanley, a COVID-19 vaccine could be a “bumper revenue opportunity“, projected to earn at least $10 billion a year. Morgan Stanley’s projection is at least $10 billion a year across developed countries but Credit Suisse is bigging it up further […]