pathogen-associated molecular pattern Archives

SARS-COV-2’s Defences Against Detection.

18 May 2021

What Variants Want. Considerable coverage is being given to variant B1.617. This is the ‘Indian’ variant if you use the incorrect basis of giving single country, geographical names to variants that appear globally across multiple variants and are not new, having been in existence for months and in some cases, over a year. As part […]

Exoribonuclease – Your Starter For Ten Mr Prime Minister.

30 December 2020

Q1. How can a virus containing an exoribonuclease mutate in the way you are saying? Coronaviruses possess an exoribonuclease within nonstructural protein 14 (nsp14-ExoN). This functions as a proofreader during viral transcription and encoding, ensuring high fidelity replication. This minimises the potential for mutation, as shown by the fact that sarbecovirus/lineage B betacoronaviruses with their […]

Mutation Makes A Vaccine Useless.

20 December 2020

Epitopes And Paratopes. Apparently the killer virus of death (the one that continues to not kill people, especially those it infects) has now mutated into an even more killer strain. If that’s true – which it isn’t, read on to find out why – then wonderdrug vaccine BNT126b2 is nothing of the sort: it was […]

Avoid Any Experimental Vaccine.

6 December 2020

The Right Vaccine Can Be Good. Few would disagree – us included – that vaccines per se are a good thing. Over the decades vaccines have been created that have eradicated or allowed the prevention of truly horrible diseases such as smallpox, polio, measles, hepatitis A & B, mumps, diptheria and whooping cough. Those of […]

Déjà vu – memory T cells have seen SARS-CoV-2 before.

23 November 2020

Newly-Discovered Is Not New. In early September we first highlighted the incorrect designation of SARS-CoV-2 as a ‘novel’ or ‘new’ coronavirus when it should have been designated ‘newly-discovered’. There is a subtle but fundamental difference: something that is new did not previously exist whereas something that is newly-discovered already existed but not been discovered yet. […]

These Are Not The Drugs You Are Looking For.

20 November 2020

Don’t Use Remdesivir. Just one month after the US Food and Drug Administration approved remdesivir as an antiviral for the treatment of patients with COVID-19, the WHO yesterday recommended that it not be used, on the basis that it is ineffective and there is “no evidence” it reduces mortality. Last month, we analysed remdesivir’s use […]