pathogenesis Archives

Why Wearing A Non-Surgical Face Covering Makes It Worse.

25 September 2021

UK COVID-19 Mortality Rate. The most straightforward, simple and transparent measure of whether non-surgical face coverings work is that even now, over 18 months into the current insanity, the UK’s COVID-19 mortality rate is 3.27-times higher than the worldwide average (@0500UTC today, source: Johns Hopkins Coronavirus Resource Center/Worldmeters). With the worldwide average being just what […]

How Low Is The SARS-CoV-2 Mortality Rate?

13 September 2021

We All Grew Up With Coronaviruses, As Did All Our Ancestors. To understand the relevance of mortality rate, you have to appreciate that coronaviruses first became pathogenic to humans in the range 12,000 – 10,000 years ago, as a consequence of the first interaction between humans and livestock that occurred in the early Holocene. Mankind […]

Tests That Would Have Saved Thousands.

13 May 2021

UK COVID-19 mortality rate remains one of the highest in the world. On a population-adjusted basis (for fair comparison) the UK mortality rate is 4.36x the worldwide average, which means there have been an additional 98,364 deaths in the UK (@0500UTC 13/05/21, source: Johns Hopkins Coronavirus Resource Center/Worldmeters). Deaths that were avoidable. One of the […]

Peak Deaths Was One Year Ago.

8 April 2021

Peak Infections And Peak Deaths. COVID-19 deaths peaked in the UK on 8th April 2020, one year ago today. This followed peak infections on 19th March 2020, a little under three weeks previous, in line with SARS-CoV-2’s infection cycle of two weeks. Week one occurs in the upper respiratory tract and includes exposure, cellular fusion […]

IgA – Faster, Stronger and More Effective.

11 March 2021

The Star Player On Your Team. Following seroconversion, immumoglobulin A (IgA) istoype is the most frequently created antibody in the immune system. This is principally because it dominates the upper respiratory tract, which is usually the first point of contact between pathogen and human. Therefore, it is needed more frequently than the other isotypes. As […]

Calcifediol (Vitamin D) Is The Most Effective Vaccine.

14 February 2021

Our Position On Calcifediol Is Validated Again. In early July 2020 we identified the importance of vitamin D in respect of SARS-CoV-2, both in terms of systematic vitamin D deficiency leading to increased COVID-19 disease severity & resultant higher mortality rates and the role of vitamin D in providing protective or sterilising immunity. Natural exposure […]

Clap For Chris – The Greatest Scientist…NOT.

6 February 2021

This Man Is Supposed To Be In Charge. Earlier this week, the Chief Medical Officer was heckled in the street by someone who disagreed with him. Perhaps not the most appropriate way to make your point – even if the point being made was absolutely correct – but if you are a true leader and […]

Nitric Oxide Immunity In The Upper Respiratory Tract.

24 January 2021

The Upper Respiratory Tract Is The Key Battleground. Back in July 2020, we first explained the crucial significance of vitamin D as an effective viral countermeasure as well as the significance of vitamin D deficiency in SARS-CoV-2’s pathogenesis and COVID-19 disease severity. Then in October we highlighted the importance of the vitamin D→endothelial nitric oxide synthase→nitric […]

Remdesivir – an antiviral for a specific narrow group but a wonderdrug for everyone else?

23 October 2020

Antiviral Not Vaccine. The US Food and Drug Administration (FDA) has given full approval to remdesivir for the treatment of COVID-19. Remdesivir has been receiving coverage since the early days of the Great Insanity – often touted as a wonderdrug – and has been in use on a compassionate patient-by-patient basis since late January as […]

Vitamin D, eNOS and NO – your partners in fighting SARS-CoV-2

3 October 2020

An Achilles heel Following on from our first article last month on key reasons why the UK government strategy & response have been so wrong and caused the deaths of tens of thousands of people, this article outlines the key roles of vitamin D, endothelial nitric oxide synthase (eNOS or NOS3) and nitric oxide in […]