pattern recognition receptor Archives

Cathelicidin – Another Key Benefit Of Vitamin D.

29 October 2021

Background. It is impossible to ignore the pivotal role of vitamin D both in preventing SARS-CoV-2 viral infection (through the eNOS→nitric oxide pathway) and in reducing COVID-19 disease severity (through the cholecalciferol→ calcifediol→calcitriol pathway). As early as July 2020 we had identified the positive correlation between COVID-19 mortality rate and vitamin D deficiency. By October […]

Why Wearing A Non-Surgical Face Covering Makes It Worse.

25 September 2021

UK COVID-19 Mortality Rate. The most straightforward, simple and transparent measure of whether non-surgical face coverings work is that even now, over 18 months into the current insanity, the UK’s COVID-19 mortality rate is 3.27-times higher than the worldwide average (@0500UTC today, source: Johns Hopkins Coronavirus Resource Center/Worldmeters). With the worldwide average being just what […]

How Low Is The SARS-CoV-2 Mortality Rate?

13 September 2021

We All Grew Up With Coronaviruses, As Did All Our Ancestors. To understand the relevance of mortality rate, you have to appreciate that coronaviruses first became pathogenic to humans in the range 12,000 – 10,000 years ago, as a consequence of the first interaction between humans and livestock that occurred in the early Holocene. Mankind […]

Antiphospholipid Antibodies And COVID-19 Vaccines.

25 August 2021

Background. As early as October 2020 – over ten months ago – we explained why a vaccine was not needed and would not be effective. That’s a vaccine using its correct medical definition, i.e. a prophylactic treatment providing long-term or lifetime protection. All of the four main treatment candidates being injected – Vaxzevria; BNT126b2; mRNA-1273 […]

SARS-COV-2’s Defences Against Detection.

18 May 2021

What Variants Want. Considerable coverage is being given to variant B1.617. This is the ‘Indian’ variant if you use the incorrect basis of giving single country, geographical names to variants that appear globally across multiple variants and are not new, having been in existence for months and in some cases, over a year. As part […]

Tests That Would Have Saved Thousands.

13 May 2021

UK COVID-19 mortality rate remains one of the highest in the world. On a population-adjusted basis (for fair comparison) the UK mortality rate is 4.36x the worldwide average, which means there have been an additional 98,364 deaths in the UK (@0500UTC 13/05/21, source: Johns Hopkins Coronavirus Resource Center/Worldmeters). Deaths that were avoidable. One of the […]

Rhinoviruses Increase SARS-CoV-2 Immunity.

31 March 2021

Persistent Antigen Exposure. We first highlighted persistent antigen exposure back in November 2020, when our research showed that individuals who had not previously had SARS-CoV-2 possessed memory T cells that recognised it, with this recognition likely coming from previous exposure to other common cold-causing coronaviruses. Public Health England that commissioned the report stated (with our […]

Why The S Protein Is Not The Target You Are Looking For.

11 February 2021

The First Lesson Of Camouflage – Not Being Seen. The majority of vaccines and antivirals both in use and in development as SARS-CoV-2 countermeasures target the structural Spike protein. We have highlighted previously that as the S protein trimers contain the RBDs, the S protein houses the virion’s principal weapon and is therefore the obvious, […]

Why Government Advice Makes It So Much Worse.

5 January 2021

Over nine months into this insanity, it is clear that government advice hasn’t worked. Following government advice doesn’t work. Not only is government advice ineffective but also it causes negative outcomes. Following government advice makes the situation worse and makes you far more likely to become seriously ill and – if you allow yourself to […]

Exoribonuclease – Your Starter For Ten Mr Prime Minister.

30 December 2020

Q1. How can a virus containing an exoribonuclease mutate in the way you are saying? Coronaviruses possess an exoribonuclease within nonstructural protein 14 (nsp14-ExoN). This functions as a proofreader during viral transcription and encoding, ensuring high fidelity replication. This minimises the potential for mutation, as shown by the fact that sarbecovirus/lineage B betacoronaviruses with their […]