What Makes SARS-CoV-2 More Infectious.

The Role Of The RBM:ACE2 Interface. A little over a year ago, we set out how increased infectiousness meant greater vulnerability, i.e. a new variant may be more infectious but it is also more susceptible to destruction by the innate immune response. The chances are that most people now know what a structural spike protein […]

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How Each Of Us Causes Every Variant.

The Four Nucleobases. Almost exactly twelve months ago, we explained how increased transmissibility also meant greater vulnerability, i.e. a new variant may be more infectious but it is also more susceptible to detection by the immune system. This was first evidenced by our study of SARS-CoV-2-SG614, also one year ago now. Despite there being virtually […]

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Yet Another Virus That Provides SARS-CoV-2 Immunity.

Background. It is difficult to select the most fundamental error relating to SARS-CoV-2: the deliberate confusion of ‘infectiousness’ with ‘infectivity’; the deliberate use of ‘COVID-19’ disease severity when one is referring to ‘SARS-CoV-2’ viral infection, for example ‘rising COVID-19 infections’ when there is no such thing; the use of ‘vaccination’ when the correct description is […]

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How Low Is The SARS-CoV-2 Mortality Rate?

We All Grew Up With Coronaviruses, As Did All Our Ancestors. To understand the relevance of mortality rate, you have to appreciate that coronaviruses first became pathogenic to humans in the range 12,000 – 10,000 years ago, as a consequence of the first interaction between humans and livestock that occurred in the early Holocene. Mankind […]

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Why Delta / B1.617.2 Is NOT A Problem.

Just What Is Different About Delta? B1.617.2/Delta is apparently still spreading.  This is unsurprising given that it has been occurring globally for over eight months. At least the WHO has finally applied a nomenclature to the main SARS-CoV-2 variants, adding to the existing PANGO and Nextstrain designations.  This validates something we first highlighted four months […]

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The ‘Third Wave’ That Has Been Here All Along.

B1.1.7 v B1.1.28 v B1.351. As we have previously explained, SARS-CoV-2 neither thinks nor acts geographically. Yet the misleading designation of SARS-CoV-2 variants on a geographical basis continues to dominate media coverage and government obsession, with the putative ‘third wave’ being down to either the Brazilian variant or the UK variant dependent upon whether you […]

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IgA – Faster, Stronger and More Effective.

The Star Player On Your Team. Following seroconversion, immumoglobulin A (IgA) istoype is the most frequently created antibody in the immune system. This is principally because it dominates the upper respiratory tract, which is usually the first point of contact between pathogen and human. Therefore, it is needed more frequently than the other isotypes. As […]

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Why Geographical Naming Of Variants Is Wrong.

B1.1.28 and B1.351 – They Are All ‘Johnny Foreigner’ Variants To The Government. In recent months, the government has made much of the emergence of new ‘killer mutations of death’, obsessing about ‘South African’ and ‘Brazilian’ geographical variants. Before going further, one should refer to these variants by their correct designations: the Brazilian variant is […]

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