receptor binding motif Archives

What Makes SARS-CoV-2 More Infectious.

12 February 2022

The Role Of The RBM:ACE2 Interface. A little over a year ago, we set out how increased infectiousness meant greater vulnerability, i.e. a new variant may be more infectious but it is also more susceptible to destruction by the innate immune response. The chances are that most people now know what a structural spike protein […]

How Low Is The SARS-CoV-2 Mortality Rate?

13 September 2021

We All Grew Up With Coronaviruses, As Did All Our Ancestors. To understand the relevance of mortality rate, you have to appreciate that coronaviruses first became pathogenic to humans in the range 12,000 – 10,000 years ago, as a consequence of the first interaction between humans and livestock that occurred in the early Holocene. Mankind […]

Why Is Nitric Oxide’s Key Role Ignored?

28 July 2021

Role In The Innate Immune Response. It is a year since we first identified the significance of vitamin D in respect of SARS-CoV-2. Through the vitamin D pathways it can both prevent viral infection and attenuate disease progression and severity. Yet the role of vitamin D-modulated nitric oxide remains largely ignored and dismissed by the NHS as […]

Why Delta / B1.617.2 Is NOT A Problem.

6 July 2021

Just What Is Different About Delta? B1.617.2/Delta is apparently still spreading. This is unsurprising given that it has been occurring globally for over eight months. At least the WHO has finally applied a nomenclature to the main SARS-CoV-2 variants, adding to the existing PANGO and Nextstrain designations. This validates something we first highlighted four months […]