replication transscription complex Archives

How Each Of Us Causes Every Variant.

31 January 2022

The Four Nucleobases. Almost exactly twelve months ago, we explained how increased transmissibility also meant greater vulnerability, i.e. a new variant may be more infectious but it is also more susceptible to detection by the immune system. This was first evidenced by our study of SARS-CoV-2-SG614, also one year ago now. Despite there being virtually […]

Nitric Oxide’s Role In Anti-Adhesion And Anti-Coagulation.

13 December 2021

Background. SARS-CoV-2’s Achilles’ heel has always been vitamin D in general and nitric oxide in particular. We first explained the relevance of vitamin D in July 2020, identifying the correlation between vitamin D deficiency and COVID-19 mortality rates and the key role of exposure to photosynthesis of vitamin D from exposure to UVB that occurs […]

Cathelicidin – Another Key Benefit Of Vitamin D.

29 October 2021

Background. It is impossible to ignore the pivotal role of vitamin D both in preventing SARS-CoV-2 viral infection (through the eNOS→nitric oxide pathway) and in reducing COVID-19 disease severity (through the cholecalciferol→ calcifediol→calcitriol pathway). As early as July 2020 we had identified the positive correlation between COVID-19 mortality rate and vitamin D deficiency. By October […]

Why Is Nitric Oxide’s Key Role Ignored?

28 July 2021

Role In The Innate Immune Response. It is a year since we first identified the significance of vitamin D in respect of SARS-CoV-2. Through the vitamin D pathways it can both prevent viral infection and attenuate disease progression and severity. Yet the role of vitamin D-modulated nitric oxide remains largely ignored and dismissed by the NHS as […]

Is Ivermectin Another ‘Wonderdrug’?

21 April 2021

Is This Remdesivirmania Redux? Ivermectin is the subject of increasing coverage and concomitant hysteria around it being another ‘wonderdrug’ for the treatment of SARS-CoV-2. It has been touted as a potential treatment since the days of remdesivir, chloroquine, hydroxychloroquine and lopinavir. We picked apart remdesivir in October 2020, days after it was approved by the […]

Rhinoviruses Increase SARS-CoV-2 Immunity.

31 March 2021

Persistent Antigen Exposure. We first highlighted persistent antigen exposure back in November 2020, when our research showed that individuals who had not previously had SARS-CoV-2 possessed memory T cells that recognised it, with this recognition likely coming from previous exposure to other common cold-causing coronaviruses. Public Health England that commissioned the report stated (with our […]

IgA – Faster, Stronger and More Effective.

11 March 2021

The Star Player On Your Team. Following seroconversion, immumoglobulin A (IgA) istoype is the most frequently created antibody in the immune system. This is principally because it dominates the upper respiratory tract, which is usually the first point of contact between pathogen and human. Therefore, it is needed more frequently than the other isotypes. As […]

Why The S Protein Is Not The Target You Are Looking For.

11 February 2021

The First Lesson Of Camouflage – Not Being Seen. The majority of vaccines and antivirals both in use and in development as SARS-CoV-2 countermeasures target the structural Spike protein. We have highlighted previously that as the S protein trimers contain the RBDs, the S protein houses the virion’s principal weapon and is therefore the obvious, […]