secretory IgA Archives

Why Is Nitric Oxide’s Key Role Ignored?

28 July 2021

Role In The Innate Immune Response. It is a year since we first identified the significance of vitamin D in respect of SARS-CoV-2. Through the vitamin D pathways it can both prevent viral infection and attenuate disease progression and severity. Yet the role of vitamin D-modulated nitric oxide remains largely ignored and dismissed by the NHS as […]

IgA – Faster, Stronger and More Effective.

11 March 2021

The Star Player On Your Team. Following seroconversion, immumoglobulin A (IgA) istoype is the most frequently created antibody in the immune system. This is principally because it dominates the upper respiratory tract, which is usually the first point of contact between pathogen and human. Therefore, it is needed more frequently than the other isotypes. As […]

Why The S Protein Is Not The Target You Are Looking For.

11 February 2021

The First Lesson Of Camouflage – Not Being Seen. The majority of vaccines and antivirals both in use and in development as SARS-CoV-2 countermeasures target the structural Spike protein. We have highlighted previously that as the S protein trimers contain the RBDs, the S protein houses the virion’s principal weapon and is therefore the obvious, […]

Why Government Advice Makes It So Much Worse.

5 January 2021

Over nine months into this insanity, it is clear that government advice hasn’t worked. Following government advice doesn’t work. Not only is government advice ineffective but also it causes negative outcomes. Following government advice makes the situation worse and makes you far more likely to become seriously ill and – if you allow yourself to […]

Exoribonuclease – Your Starter For Ten Mr Prime Minister.

30 December 2020

Q1. How can a virus containing an exoribonuclease mutate in the way you are saying? Coronaviruses possess an exoribonuclease within nonstructural protein 14 (nsp14-ExoN). This functions as a proofreader during viral transcription and encoding, ensuring high fidelity replication. This minimises the potential for mutation, as shown by the fact that sarbecovirus/lineage B betacoronaviruses with their […]