structural protein Archives

What Makes SARS-CoV-2 More Infectious.

12 February 2022

The Role Of The RBM:ACE2 Interface. A little over a year ago, we set out how increased infectiousness meant greater vulnerability, i.e. a new variant may be more infectious but it is also more susceptible to destruction by the innate immune response. The chances are that most people now know what a structural spike protein […]

Cathelicidin – Another Key Benefit Of Vitamin D.

29 October 2021

Background. It is impossible to ignore the pivotal role of vitamin D both in preventing SARS-CoV-2 viral infection (through the eNOS→nitric oxide pathway) and in reducing COVID-19 disease severity (through the cholecalciferol→ calcifediol→calcitriol pathway). As early as July 2020 we had identified the positive correlation between COVID-19 mortality rate and vitamin D deficiency. By October […]

Why Delta / B1.617.2 Is NOT A Problem.

6 July 2021

Just What Is Different About Delta? B1.617.2/Delta is apparently still spreading. This is unsurprising given that it has been occurring globally for over eight months. At least the WHO has finally applied a nomenclature to the main SARS-CoV-2 variants, adding to the existing PANGO and Nextstrain designations. This validates something we first highlighted four months […]

SARS-COV-2’s Defences Against Detection.

18 May 2021

What Variants Want. Considerable coverage is being given to variant B1.617. This is the ‘Indian’ variant if you use the incorrect basis of giving single country, geographical names to variants that appear globally across multiple variants and are not new, having been in existence for months and in some cases, over a year. As part […]

Is Ivermectin Another ‘Wonderdrug’?

21 April 2021

Is This Remdesivirmania Redux? Ivermectin is the subject of increasing coverage and concomitant hysteria around it being another ‘wonderdrug’ for the treatment of SARS-CoV-2. It has been touted as a potential treatment since the days of remdesivir, chloroquine, hydroxychloroquine and lopinavir. We picked apart remdesivir in October 2020, days after it was approved by the […]

IgA – Faster, Stronger and More Effective.

11 March 2021

The Star Player On Your Team. Following seroconversion, immumoglobulin A (IgA) istoype is the most frequently created antibody in the immune system. This is principally because it dominates the upper respiratory tract, which is usually the first point of contact between pathogen and human. Therefore, it is needed more frequently than the other isotypes. As […]

Why The S Protein Is Not The Target You Are Looking For.

11 February 2021

The First Lesson Of Camouflage – Not Being Seen. The majority of vaccines and antivirals both in use and in development as SARS-CoV-2 countermeasures target the structural Spike protein. We have highlighted previously that as the S protein trimers contain the RBDs, the S protein houses the virion’s principal weapon and is therefore the obvious, […]

N501Y Is More Infectious But NOT More Dangerous.

13 January 2021

Infectiousness Or Infectivity. If the government is to be believed, the new killer mutant of death (no, not vaccines minister Zoonotic Gaddafi, the other killer mutant of death known as N501Y) is even more infectious and even more transmissible. Except the government likes to confuse viral infectiousness with disease severity. They are very different. Also, […]

PCR Testing Is Picking Up The Common Cold.

23 December 2020

Mutation = Phylogenetic Evolution. Not content with inventing the most recent ‘killer mutation of death’, there are now apparently even more new strains of the ‘killer virus of death’ (the one that continues to not kill people, especially those it infects). There is now even one supposedly from South Africa (“this is an illegal mutating, […]

Mutation Makes A Vaccine Useless.

20 December 2020

Epitopes And Paratopes. Apparently the killer virus of death (the one that continues to not kill people, especially those it infects) has now mutated into an even more killer strain. If that’s true – which it isn’t, read on to find out why – then wonderdrug vaccine BNT126b2 is nothing of the sort: it was […]